The BCL2L13 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to BCL2 like 13, and BCL2L13. This antibody recognizes Human, Mouse, and Rat antigen. The BCL2L13 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.
Function: May promote the activation of caspase-3 and apoptosis.
Subunit Structure: Monomer.
Similarity: Belongs to the Bcl-2 family